Which neuroreceptors mediate the subjective effects of MDMA in humans? A summary of mechanistic studies

@article{Liechti2001WhichNM,
  title={Which neuroreceptors mediate the subjective effects of MDMA in humans? A summary of mechanistic studies},
  author={M. Liechti and F. Vollenweider},
  journal={Human Psychopharmacology: Clinical and Experimental},
  year={2001},
  volume={16}
}
In preclinical studies, 3,4‐methylenedioxymethamphetamine (MDMA, ‘Ecstasy’) has been shown to release serotonin (5‐HT), dopamine and norepinephrine. However, the role of these neurotransmitters and their corresponding receptor sites in mediating the subjective effects of MDMA has not yet been studied in humans. Therefore, we investigated the effects of three different neuroreceptor pretreatments on the subjective, cardiovascular and adverse effects of MDMA (1.5 mg/kg orally) in 44 healthy human… Expand
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