Which is the most conserved group of proteins? Homology-orthology, paralogy, xenology, and the fusion of independent lineages

  title={Which is the most conserved group of proteins? Homology-orthology, paralogy, xenology, and the fusion of independent lineages},
  author={Johann Peter Gogarten},
  journal={Journal of Molecular Evolution},
  • J. Gogarten
  • Published 1 November 1994
  • Biology
  • Journal of Molecular Evolution
Safety in numbers: multiple occurrences of highly similar homologs among Azotobacter vinelandii carbohydrate metabolism proteins probably confer adaptive benefits
It is shown that large numbers of highly similar synologs among carbohydrate metabolism genes are very rare in bacterial and archaeal genomes, and that the A. vinelandii DJ genome contains an unusually large amount of suchsynologs.
OP-GBEV210166 1..17
A robust taxonomic sampling of Archaeal genomes that spans the Asgardarchaea, TACK Group, euryarchaeota, and the DPANN superphylum is sampled andylogenies derived from these data imply that the highly conserved ATP synthase catalytic/noncatalytic subunits of Nanohaloarchaea share a sisterhood relationship with the Haloarchaea.
Phage-Phage, Phage-Bacteria, and Phage-Environment Communication
In this chapter, phage-associated communication is explored including, particularly, in terms of its impact on phage ecology.
The Evolutionary Origins of Extreme Halophilic Archaeal Lineages
This work presents and evaluates data that argue for and against the monophyly of the DPANN superphylum, in particular, the inclusion of the Nanohaloarchaea in DPANN, and presents a novel gene family distance clustering strategy which shows this sisterhood relationship is not likely the result of a recent gene transfer.
Intrinsic protein disorder reduces small-scale gene duplicability
It is shown that, in general, proteins encoded by duplicated genes tend to be less disordered than those encoded by singletons, and that IDRs facilitate retention of duplicates in the context of WGD.
Calcium-dependent Protein Kinases: Understanding Functional Diversification and Specificity of Plant Signalling Hubs Using the Most Conserved Members
This chapter discusses the literature review of gene function in plants, which focused on transgenic plants, and the structure of CPKs, a type ofopolymer found inopolymer-like structures found iniary tissue ofiary plants.
Orthologues, Paralogues and Horizontal Gene Transfer in the Human Holobiont
The human is considered as a holobiont, a complex ecosystem whose evolutionary fitness is determined by interactions of the host, the symbionts and their interactions, and changes in the number of paralogues in humans reveal genomic regions under selective pressures.
Distribution and evolution of the mobile vma-1b intein.
It is shown that the vma-1b intein is present in more lineages than previously annotated, including a bacterial lineage, Mahella australiensis 50-1 BON, and evidence is presented, through ancestral character state reconstruction and substitution ratios between host genes and inteins, for several transfers of this Intein between divergent species, including an interdomain transfer between the archaea and bacteria.
The tree of life: metaphor, model, and heuristic device.
As biologists identify more entities and events to describe—including species, organisms, cells, genomes, gene families, extra-chromosomal genetic elements, endosymbioses, hybridizations, recombination types, and lateral gene transfer events—the tree of life strains under the weight of multiple uses and expectations.


Evolution of antibiotic resistance genes: the DNA sequence of a kanamycin resistance gene from Staphylococcus aureus.
The kanamycin resistance gene from Staphylococcus aureus has been sequenced and its structure compared with similar genes isolated from Streptomyces fradiae and from two transposons, originally isolated from Klebsiella pneumoniae and Salmonella typhimurium, respectively, suggest that homologous genes of this type be called xenologous.
Evolution of HSP70 gene and its implications regarding relationships between archaebacteria, eubacteria, and eukaryotes
Detailed phylogenetic analyses of HSP70 sequence data provide evidence that archaebacteria are not monophyletic and show a close evolutionary linkage with the gram-positive eubacteria, and results do not support the traditionalarchaebacterial tree, where a close relationship between arch aebacterial and eukaryotic homologs is observed.
Evolution of the vacuolar H+-ATPase: implications for the origin of eukaryotes.
It is reported that the same vacuolar H-ATPase subunits are approximately equal to 50% identical to the alpha and beta subunits, respectively, of the sulfur-metabolizing Sulfolobus acidocaldarius, an archaebacterium (Archaeobacterium).
Cloning and sequencing of the gene encoding glutamine synthetase I from the archaeum Pyrococcus woesei: anomalous phylogenies inferred from analysis of archaeal and bacterial glutamine synthetase I sequences
The possibility is presented that the GSI gene arose among the archaea and was then laterally transferred from some early methanogen to a Thermotoga-like organism.
Protein splicing converts the yeast TFP1 gene product to the 69-kD subunit of the vacuolar H(+)-adenosine triphosphatase.
Evidence is presented that both the 69-kilodalton (kD) catalytic subunit of the vacuolar proton-translocating adenosine triphosphatase (H(+)-ATPase) and a 50-kD protein are obtained from a single translation product that is cleaved to release the 50- kD protein and spliced to form the 69 -kD subunit.
Evolution of the glutamine synthetase gene, one of the oldest existing and functioning genes.
It is suggested that GS genes are one of the oldest existing and functioning genes in the history of gene evolution and that GSI genes should also exist in eukaryotes.
Horizontal transfer of ATPase genes--the tree of life becomes a net of life.