Whey proteins and peptides: beneficial effects on immune health

@article{Beaulieu2006WheyPA,
  title={Whey proteins and peptides: beneficial effects on immune health},
  author={Jos{\'e}e Beaulieu and Claude Dupont and Pierre Lemieux},
  journal={Therapy},
  year={2006},
  volume={3},
  pages={69-78}
}
Over the last decade, natural health products have been the subject of immense infatuation in the scientific community, in particular with immunologists. Numerous recent studies have demonstrated important effects on all facets of immunity – from the stimulation of innate and adaptive immunity, to an anti-inflammatory effect of these products. In many of these enhancing health products, whey proteins and whey peptides are present, which, for many years, have been well known for their benefits… 
View via Publisher
44 Citations
Highly Influential Citations
1
Background Citations
19

Tables from this paper

44 Citations

Immunomodulation by a malleable matrix composed of fermented whey proteins and lactic acid bacteria.

The stimulation of the immune system by MPM consumption was evident as seen by the increased polymorphonuclear cell counts and intracellular glutathione levels, and the absence ofMPM-specific antibody production indicated a lack of undesirable immune recognition of MPM.

Why whey? Camel whey protein as a new dietary approach to the management of free radicals and for the treatment of different health disorders

The current review presents a concise summary of the scientific evidence of the beneficial effects of CWP to support its therapeutic use in disease treatment and nutritional intervention.

animal based bioactives for health and wellness

Animal based bioactives are potentially involved as protective compounds for a number of chronic diseases and can be used as good health food.

Anti-inflammatory potential of a malleable matrix composed of fermented whey proteins and lactic acid bacteria in an atopic dermatitis model

The anti-inflammatory activity demonstrated in the ACD model suggests that the mechanism of action of the MPM is different than that of hydrocortisone and could become a relevant product for people suffering from dermatological manifestations associated with immune dysfunctions such as allergies, eczema, dermatitis, and autoimmune diseases.

Functional Aspects of Dairy Foods in Human Health: An Overview

This paper reviews and discusses some of the latest findings regarding the role of milk and dairy products as functional foods.

Beneficial health effects of milk and fermented dairy products — Review

There has been growing evidence of the role that dairy proteins play in the regulation of satiety, food intake and obesity-related metabolic disorders.

Mécanismes d'action d'un extrait protéique du lactosérum bovin sur les fonctions du neutrophile humain

In vivo, WPE ameliorated TNBS-induced inflammation with efficacy ranging from 8 to 240 mg/kg/d, and provided insight on the role and the mechanisms of action of bovine whey proteins on the innate immune system, and more specifically on neutrophils.

Camel whey protein improves lymphocyte function and protects against diabetes in the offspring of diabetic mouse dams

Evidence is provided of a protective role of CWP in decreasing the tendency of the offspring of diabetic mothers to develop diabetes and related complications and the chemotaxis of B- and T-lymphocytes toward CCL21 and CXCL12 and the proliferative capacities of these lymphocytes were restored in the male offspring of diabetes mice administered CWP.

Degalactosylated Whey Protein Suppresses Inflammatory Responses Induced by Lipopolysaccharide in Mice

It is suggested that degalactosylated whey protein suppresses the effects of LPS in part by decreasing in TLR4 and increasing in MKP-1.

Inhibition of neutrophil infiltration by a malleable protein matrix of lactic acid bacteria-fermented whey proteins in vivo

MPM administration demonstrates a significant reduction of neutrophil infiltration associated with an inhibition of cytokine and chemokine production, and the air pouch model shares similarities with in vivo characteristics of rheumatoid arthritis and neutrophilic diseases.

References

SHOWING 1-10 OF 102 REFERENCES

Immunomodulatory effects of dietary whey proteins in mice.

The present results confirm other previous results that dietary bovine milk whey proteins have immunoenhancing properties in mice and these properties are unlikely to be related solely to the nutritional effects.

Immunologic effects of yogurt.

The hypothesis that increased yogurt consumption, particularly in immunocompromised populations such as the elderly, may enhance the immune response, which would in turn increase resistance to immune-related diseases is supported.

Effects of purified bovine whey factors on cellular immune functions in ruminants.

Modulation of immune function by a modified bovine whey protein concentrate

A modified whey protein concentrate derived as a by‐product from the commercial manufacture of cheese was tested for its ability to modulate murine immune function in vitro, andenzymatic digestion by pepsin and pancreatin ablated the immunomodulatory function of the mWPC.

Immunomodulating effects of whey proteins and their enzymatic digests

Immunostimulatory potential of beta-lactoglobulin preparations: effects caused by endotoxin contamination.

Immunoenhancing property of dietary whey protein in mice: role of glutathione.

The present study indicates that the observed immunoenhancing effect of the whey protein mixture is dependent on the overall amino acid pattern resulting from the contribution of all its protein components.

The biological activity of undenatured dietary whey proteins: role of glutathione.

  • G. BounousP. Gold
  • Biology, Medicine
    Clinical and investigative medicine. Medecine clinique et experimentale
  • 1991
The data indicate that the humoral immune response is highest in mice fed a dietary whey protein concentrate exhibiting the highest solubility (undenatured conformation) and a greater relative concentration of the thermolabile bovine serum albumin and immunoglobulins.

Immune modulation in suckling rat pups by a growth factor extract derived from milk whey

It is shown that daily oral administration of a growth factor-enriched fraction from milk whey to naturally suckling rat pups between days 4–9 postnatal can down-regulate immune activation to a specific orally administered food antigen, ovalbumin, assessed by lymphocyte proliferation.

Enhancement of Mucosal Antibody Responses by Dietary Whey Protein Concentrate

This study confirms previous reports that dietary bovine whey protein concentrate can potentiate humoral immunity in mice, and provides the first evidence that WPC can enhance mucosal antibody responses to orally-administered antigens.
...