Where to cross? New insights into the location of meiotic crossovers.


During meiosis, the repair of induced DNA double-strand breaks (DSBs) produces crossovers (COs). COs are essential for the proper segregation of homologous chromosomes at the first meiotic division. In addition, COs generate new combinations of genetic markers in the progeny. CO localization is tightly controlled, giving rise to patterns that are specific… (More)
DOI: 10.1016/j.tig.2015.03.008