Where no Ras has gone before: VPS35 steers N-Ras through the cytosol.

Abstract

Ras is the best-studied member of the superfamily of small GTPases because of its role in cancer. Ras proteins transmit signals for proliferation, differentiation and survival. Three RAS genes encode 4 isoforms. All Ras isoforms have long been considered membrane bound, a localization required for function. Our recent study revealed that N-Ras differs from… (More)
DOI: 10.1080/21541248.2016.1263380

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