Where is the Clinical Breakthrough of Heme Oxygenase-1 / Carbon Monoxide Therapeutics?

@article{Hopper2018WhereIT,
  title={Where is the Clinical Breakthrough of Heme Oxygenase-1 / Carbon Monoxide Therapeutics?},
  author={Christopher P. Hopper and Lorenz Meinel and Christoph Steiger and Leo E. Otterbein},
  journal={Current pharmaceutical design},
  year={2018},
  volume={24 20},
  pages={
          2264-2282
        }
}
Heme oxygenase (HO), the rate-limiting step in the degradation of heme to biliverdin, ferrous ion, and carbon monoxide (CO), is an ancestral protective enzyme conserved across phylogenetic domains. While HO was first described in the late 1960s and progressively characterized in the following decades, there has been a surge of innovation over the past twenty years in efforts to leverage the cytoprotective power of HO in a clinical setting. Despite the plethora of preclinical data indicating… 
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