Where is mTOR and what is it doing there?

Abstract

Target of rapamycin (TOR) forms two conserved, structurally distinct kinase complexes termed TOR complex 1 (TORC1) and TORC2. Each complex phosphorylates a different set of substrates to regulate cell growth. In mammals, mTOR is stimulated by nutrients and growth factors and inhibited by stress to ensure that cells grow only during favorable conditions. Studies in different organisms have reported localization of TOR to several distinct subcellular compartments. Notably, the finding that mTORC1 is localized to the lysosome has significantly enhanced our understanding of mTORC1 regulation. Subcellular localization may be a general principle used by TOR to enact precise spatial and temporal control of cell growth.

DOI: 10.1083/jcb.201306041

Extracted Key Phrases

5 Figures and Tables

01002003002014201520162017
Citations per Year

763 Citations

Semantic Scholar estimates that this publication has 763 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@inproceedings{Betz2013WhereIM, title={Where is mTOR and what is it doing there?}, author={Charles Betz and Michael N. Hall}, booktitle={The Journal of cell biology}, year={2013} }