Where is dihydroergotamine mesylate in the changing landscape of migraine therapy?

@article{Morren2010WhereID,
  title={Where is dihydroergotamine mesylate in the changing landscape of migraine therapy?},
  author={John Anthony Morren and Néstor Gálvez-Jiménez},
  journal={Expert Opinion on Pharmacotherapy},
  year={2010},
  volume={11},
  pages={3085 - 3093}
}
Importance of the field: Migraine affects approximately 18% of women and 6% of men, and has an immense impact on quality of life and productivity. Advancement in therapeutic options has been slow. For many patients with difficult-to-treat migraine, the appropriate use of dihydroergotamine mesylate (DHE) can result in treatment success and unprecedented patient satisfaction. Areas covered in this review: Migraine treatment guidelines regarding the role of DHE are highlighted. An overview of the… 

Dihydroergotamine (DHE) – Is there a place for its use?

TLDR
Most clinical data confirm that the drug is still an important element of contemporary migraine therapy, especially in cases when conventional medicine fails, and its role in modern therapy based on available clinical trials is confirmed.

MAP0004: dihydroergotamine mesylate inhalation aerosol for acute treatment of migraine

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Both Phase II and III clinical trials support anti-migraine efficacy with superior tolerability withMAP0004 compared with intravenous DHE, and the future use of MAP0004 as a first-line acute migraine treatment is supported.

Intravenous Dihydroergotamine Therapy for Pediatric Abdominal Migraines

TLDR
DHE may be a treatment option in children with intractable abdominal migraine after being used when other agents like amitriptyline, verapamil, topiramate, or depakote had proved ineffective.

Dihydroergotamine: A Review of Formulation Approaches For the Acute Treatment of Migraine

TLDR
Among parenteral formulations (including subcutaneous, intramuscular, intravenous and nasal spray), efficacy is superior with injectable dosing, but there are no head-to-head comparisons with triptans available for review.

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  • D. Reddy
  • Medicine
    Expert review of clinical pharmacology
  • 2013
TLDR
There are several agents for prevention of migraine occurrence in patients with frequent or severe disabling migraine attacks and new drugs with improved efficacy and reduced side effects are needed for effective treatment and Prevention of migraine.

Delivery of Dihydroergotamine Mesylate to the Upper Nasal Space for the Acute Treatment of Migraine: Technology in Action.

TLDR
Precision Olfactory Delivery technology may have the potential to overcome the limitations of traditional nasal delivery systems, while utilizing the nasal delivery benefits of GI tract avoidance, rapid onset, patient convenience, and ease of use.

Dihydroergotamine mesylate‐loaded dissolving microneedle patch made of polyvinylpyrrolidone for management of acute migraine therapy

  • C. TasJ. Joyce M. Prausnitz
  • Medicine
    Journal of controlled release : official journal of the Controlled Release Society
  • 2017

MIGRAINE - A COMPREHENSIVE REVIEW

TLDR
Migraine may bring a suffering phase in an individual's schedule yet it can be handled with the familiarity of some self-care remedies and by making simple modifications in the routine lifestyle, which may facilitate to pave the clear way to recovery and make things easier for migraine management.

Current Approach to Undifferentiated Headache Management in the Emergency Department

TLDR
Antidopaminergics have an established role in the management of acute, severe, headache with manageable side-effect profiles, however, recent studies suggest anesthetic and anti-epileptic drugs may play roles in headache treatment in the ED.

Development and in vitro/in vivo evaluation of dihydroergotamine mesylate loaded maltodextrin-pullulan sublingual films

TLDR
It is suggested that the polymer combinations of pullulan and maltodextrin formed successful films and were considered as an alternative dosage form for DHE in migraine therapy.

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