Where do you know what you know? The representation of semantic knowledge in the human brain

@article{Patterson2007WhereDY,
  title={Where do you know what you know? The representation of semantic knowledge in the human brain},
  author={Karalyn E Patterson and Peter J. Nestor and Timothy T. Rogers},
  journal={Nature Reviews Neuroscience},
  year={2007},
  volume={8},
  pages={976-987}
}
Mr M, a patient with semantic dementia — a neurodegenerative disease that is characterized by the gradual deterioration of semantic memory — was being driven through the countryside to visit a friend and was able to remind his wife where to turn along the not-recently-travelled route. Then, pointing at the sheep in the field, he asked her “What are those things?” Prior to the onset of symptoms in his late 40s, this man had normal semantic memory. What has gone wrong in his brain to produce this… 
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References

SHOWING 1-10 OF 118 REFERENCES

Neuroimaging studies of semantic memory: inferring “how” from “where”

Loss of semantic memory: implications for the modularity of mind

Abstract We report a patient, PP, with semantic dementia who was studied longitudinally over two years. During this period she showed a progressive and profound loss of semantic memory affecting…

Knowledge of famous faces and names in semantic dementia.

TLDR
The findings of an examination of famous face and name knowledge in patients with semantic dementia are interpreted as inconsistent with a unitary, amodal model of semantic memory, and lead to argue that the focal syndrome of progressive prosopagnosia is one of the clinical presentations of semantic dementia and not a separate clinical entity.

Deficits of knowledge versus executive control in semantic cognition: Insights from cued naming

Structure and deterioration of semantic memory: a neuropsychological and computational investigation.

TLDR
The authors present a parallel distributed processing implementation of this theory, in which semantic representations emerge from mechanisms that acquire the mappings between visual representations of objects and their verbal descriptions, to understand the structure of impaired performance in patients with selective and progressive impairments of conceptual knowledge.

Charting the progression in semantic dementia: implications for the organisation of semantic memory.

TLDR
The data presented here address the controversy concerning the hierarchical organisation of semantic memory and suggest a progressive loss of the features of semantic representations that enable discrimination between specific category instances.

The nature of semantic memory deficits in Alzheimer's disease: new insights from hyperpriming effects.

TLDR
The results show that in Alzheimer's disease the semantic priming effects vary according to the degree of attribute loss, and the presence of hyperpriming would reflect semantic memory deficits.

Neural basis for semantic memory difficulty in Alzheimer's disease: an fMRI study.

TLDR
Functional MRI evaluation of the neural basis for impaired semantic memory for ANIMALS and IMPLEMENTS in patients with Alzheimer's disease and 16 healthy seniors is consistent with a two-component model of semantic memory involving category-neutral processes operating on category- specific knowledge.

The role of conceptual knowledge in object use evidence from semantic dementia.

TLDR
The results suggest that object use is heavily dependent upon object-specific conceptual knowledge, supplemented to some degree by a combination of visual affordances and mechanical problem solving.

Presemantic Cognition in Semantic Dementia: Six Deficits in Search of an Explanation

TLDR
It is argued that patients with semantic dementia would reveal a specific pattern of impairment on six different tasks typically considered pre- or non- semantic: reading aloud, writing to dictation, inflecting verbs, lexical decision, object decision, and delayed copy drawing are a principled consequence of a primary semantic impairment.
...