Where did bone come from?

  title={Where did bone come from?},
  author={Darja Obradovic Wagner and Per Aspenberg},
  booktitle={Acta orthopaedica},
Bone is specific to vertebrates, and originated as mineralization around the basal membrane of the throat or skin, giving rise to tooth-like structures and protective shields in animals with a soft cartilage-like endoskeleton. A combination of fossil anatomy and genetic information from modern species has improved our understanding of the evolution of bone. Thus, even in man, there are still similarities in the molecular regulation of skin appendages and bone. This article gives a brief… CONTINUE READING