Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis.

@article{Nguyen2007WhereFR,
  title={Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis.},
  author={Linh L T Nguyen and Jonathan Jacobs and Diane Mathis and C. Benoist},
  journal={Arthritis and rheumatism},
  year={2007},
  volume={56 2},
  pages={509-20}
}
OBJECTIVE Regulatory T cells play a suppressive role in many autoimmune diseases and can potentially affect various steps in the progression of disease. The purpose of this study was to analyze the role of Treg cells in the control of arthritis development. METHODS Using crosses and cell transfers, we tested the effect of the scurfy loss-of-function mutation of the Foxp3 gene in the K/BxN mouse model. In this model, arthritis develops as the result of the production of high levels of… CONTINUE READING
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