Where EGF receptors transmit their signals.

  title={Where EGF receptors transmit their signals.},
  author={Nancy L. Lill and Nurettin Ilter Sever},
  journal={Science signaling},
  volume={5 243},
Excessive signaling by receptor tyrosine kinases (RTKs) can cause cancer. What molecular mechanisms normally control RTK signaling? Are they defective in tumors? If so, should therapeutics be developed to restore particular regulatory pathways to cancer cells? These questions have been approached through mechanistic studies of a prototypical RTK, the… CONTINUE READING