When to start antiretroviral therapy: as soon as possible

  title={When to start antiretroviral therapy: as soon as possible},
  author={Ricardo A. Franco and Michael S Saag},
  booktitle={BMC medicine},
BACKGROUND The debate regarding 'When to Start' antiretroviral therapy has raged since the introduction of zidovudine in 1987. Based on the entry criteria for the original Burroughs Wellcome 002 study, the field has been anchored to CD4 cell counts as the prime metric to indicate treatment initiation for asymptomatic individuals infected with Human Immunodeficiency Virus. The pendulum has swung back and forth based mostly on the relative efficacy, toxicity and convenience of available regimens… CONTINUE READING
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