When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction.

@article{ONeill2008WhenSP,
  title={When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction.},
  author={Luke A J O'Neill},
  journal={Immunity},
  year={2008},
  volume={29 1},
  pages={12-20}
}
Toll-like receptor (TLR) signaling is subjected to crosstalk from other signals, with a resulting positive or negative effect. There is complex crosstalk between the NLR family of immune-regulatory molecules and TLRs, and C-type lectin receptors such as Dectin-1 synergize with TLR2 via the tyrosine kinase Syk. Bruton's tyrosine kinase plays an important positive role in TLR signaling, whereas the TAM family of receptor tyrosine kinases is inhibitory. The tyrosine phosphatase SHP1 has been shown… CONTINUE READING
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