When one plus one makes three: the quest for rational antiepileptic polytherapy with supraadditive anticonvulsant efficacy.

@article{Brigo2013WhenOP,
  title={When one plus one makes three: the quest for rational antiepileptic polytherapy with supraadditive anticonvulsant efficacy.},
  author={Francesco Brigo and Harald Ausserer and Frediano Tezzon and Raffaele Nardone},
  journal={Epilepsy & behavior : E&B},
  year={2013},
  volume={27 3},
  pages={439-42}
}
The experimental and clinical evidence in support of "rational polytherapy" is sparse, and to date, no clear evidence-based indications can be made to help physicians in their choice of a specific drug combination against specific forms of epilepsy. This article briefly reviews the data available in the literature and obtained from studies conducted in humans to evaluate which main AED combinations might possess supraadditive, synergistic effects in terms of efficacy, with infraadditive… CONTINUE READING

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