When metals compete: a case of copper-deficiency myeloneuropathy and anemia

@article{Spain2009WhenMC,
  title={When metals compete: a case of copper-deficiency myeloneuropathy and anemia},
  author={Rebecca I Spain and Thomas P. Leist and Eduardo A. De Sousa},
  journal={Nature Clinical Practice Neurology},
  year={2009},
  volume={5},
  pages={106-111}
}
Background A 47-year-old woman with an otherwise unremarkable medical history was referred to the multiple sclerosis clinic by her primary neurologist for evaluation of a 2–3 year history of progressive knee and back pain, weakness, paresthesias, sensory loss, ataxia, and falls. During the same period, she had received blood transfusions for unexplained anemia and leukopenia. She had been wearing dentures for many years.Investigations Physical examination, neurological examinations (assessments… 
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32 Citations
Background Citations
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32 Citations

[Peripheral neuropathy, myelopathy, cerebellar ataxia, and subclinical optic neuropathy associated with copper deficiency occurring 23 years after total gastrectomy].
We report a 61-year-old man with slowly progressive gait disturbance and paresthesia in the lower extremities following a total gastrectomy for gastric cancer 23 years previously. The patient…
Copper deficiency myelopathy probably caused by long-lasting daily excessive intake of zink.
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A 39-year-old woman with slowly progressive spastic gait and paresthesia in the lower extremities and extreme unbalanced diet of having 15-20 oysters everyday over 5 years is reported, considered that zinc excess caused copper deficiency myelopathy.
Approach to a case of myeloneuropathy
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The pattern of neurologic involvement and results obtained from a battery of biochemical tests often help in establishing the correct diagnosis of myeloneuropathy, a frequently encountered condition and often poses a diagnostic challenge.
The role of the clinical biochemist in detection of zinc-induced copper deficiency
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A middle-aged woman with neutropenia and ataxia was found to have raised plasma zinc and profoundly low plasma copper concentrations and after the zinc prescription was stopped, her copper and zinc concentrations and neutropy normalized but she only had partial improvement in neurological status.
Zinc-containing denture adhesive: a potential source of excess zinc resulting in copper deficiency myelopathy
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A case of a 58-year-old man diagnosed with copper deficiency myelopathy possibly due to zinc-containing denture cream overuse is presented.
Neurologic presentations of nutritional deficiencies.
ATP7A-related copper transport diseases—emerging concepts and future trends
  • S. Kaler
  • Biology
    Nature Reviews Neurology
  • 2011
TLDR
It is indicated that ATP7A has a crucial but previously unappreciated role in motor neuron maintenance, and that the mechanism underlying ATP 7A-related distal motor neuropathy is distinct from Menkes disease and OHS pathophysiology.
Inherited Disorders of Human Copper Metabolism
  • S. Kaler, S. Packman
  • Biology, Medicine
    Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics
  • 2021
Missense mutations in the copper transporter gene ATP7A cause X-linked distal hereditary motor neuropathy.
A female with progressive four-limb paresthesias and gait difficulty.
TLDR
A case of progressive four-limb paresthesias and gait difficulty in a female who had previously undergone gastric bypass surgery is discussed.
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