When metals compete: a case of copper-deficiency myeloneuropathy and anemia

@article{Spain2009WhenMC,
  title={When metals compete: a case of copper-deficiency myeloneuropathy and anemia},
  author={R. Spain and T. Leist and E. Sousa},
  journal={Nature Clinical Practice Neurology},
  year={2009},
  volume={5},
  pages={106-111}
}
Background A 47-year-old woman with an otherwise unremarkable medical history was referred to the multiple sclerosis clinic by her primary neurologist for evaluation of a 2–3 year history of progressive knee and back pain, weakness, paresthesias, sensory loss, ataxia, and falls. During the same period, she had received blood transfusions for unexplained anemia and leukopenia. She had been wearing dentures for many years.Investigations Physical examination, neurological examinations (assessments… Expand
Zinc poisoning from excessive denture fixative use masquerading as myelopolyneuropathy and hypocupraemia
TLDR
Questioning a patient about their denture fixative usage and checking if zinc is an ingredient may be considered during an investigation for myelopolyneuropathy when vitamin B12 deficiency is not a cause. Expand
[Peripheral neuropathy, myelopathy, cerebellar ataxia, and subclinical optic neuropathy associated with copper deficiency occurring 23 years after total gastrectomy].
We report a 61-year-old man with slowly progressive gait disturbance and paresthesia in the lower extremities following a total gastrectomy for gastric cancer 23 years previously. The patientExpand
Cervical MRI of subacute myelo-optico-neuropathy
TLDR
MRI findings of old SMON patients are presented and it is suggested that these findings are useful to study the mechanism of clioquinol toxicity before using it to treat neurodegenerative diseases such as Alzheimer's disease. Expand
Copper deficiency myelopathy probably caused by long-lasting daily excessive intake of zink.
TLDR
A 39-year-old woman with slowly progressive spastic gait and paresthesia in the lower extremities and extreme unbalanced diet of having 15-20 oysters everyday over 5 years is reported, considered that zinc excess caused copper deficiency myelopathy. Expand
Approach to a case of myeloneuropathy
TLDR
The pattern of neurologic involvement and results obtained from a battery of biochemical tests often help in establishing the correct diagnosis of myeloneuropathy, a frequently encountered condition and often poses a diagnostic challenge. Expand
The role of the clinical biochemist in detection of zinc-induced copper deficiency
TLDR
A middle-aged woman with neutropenia and ataxia was found to have raised plasma zinc and profoundly low plasma copper concentrations and after the zinc prescription was stopped, her copper and zinc concentrations and neutropy normalized but she only had partial improvement in neurological status. Expand
The Miller Fisher Syndrome
TLDR
The eponym Miller Fisher syndrome (MFS) was named after Dr. Charles Miller Fisher after he described 3 patients with acute onset of ophthalmoplegia, ataxia and areflexia that followed acute upper respiratory infections in 1956. Expand
Zinc-containing denture adhesive: a potential source of excess zinc resulting in copper deficiency myelopathy
TLDR
A case of a 58-year-old man diagnosed with copper deficiency myelopathy possibly due to zinc-containing denture cream overuse is presented. Expand
Neural effects in copper deficient Menkes disease: ATP7A-a distinctive marker
TLDR
This review focused on the normal physiological function of the ATP7A gene with respect to their harmful outcome of the mutated gene and its associated deficiency which detriments the neural mechanism in Menkes patients. Expand
Neurologic presentations of nutritional deficiencies.
TLDR
This review discusses neurologic manifestations related to deficiency of key nutrients such as vitamin B(12), folate, copper, vitamin E, thiamine, and others and includes neurologic presentations caused by nutrient deficiencies in the setting of alcoholism. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 18 REFERENCES
Copper deficiency-associated myelopathy in a 45-year-old woman
TLDR
Examination in the neurological department revealed severe spastic tetraparesis, bilateral extensor spasms, impaired sensory sense for all qualities, painful paraesthesiae from T1 downwards, and a sensory ataxic gait. Expand
Copper deficiency myelopathy produces a clinical picture like subacute combined degeneration
TLDR
Unrecognized copper deficiency appears to be a common cause of idiopathic myelopathy in adults, and early recognition and copper supplementation may prevent neurologic deterioration. Expand
[Pancytopenia, arthralgia and myeloneuropathy due to copper deficiency].
TLDR
Copper deficiency may be a differential diagnosis for hematologic abnormalities like pancytopenia, even if a disorder of intestinal resorption or a proteinuria occurs, and myeloneuropathy is a rare complication of this deficiency. Expand
Copper deficiency myelopathy (human swayback).
TLDR
Patients with copper deficiency myelopathy seen at the Mayo Clinic in Rochester, Minn, are described and the literature on neurological manifestations of acquired copper deficiency in humans is reviewed. Expand
Copper deficiency myelopathy induced by repetitive parenteral zinc supplementation during chronic hemodialysis
TLDR
A 61 year old woman with a 6 month history of progressive gait ataxia, lower limb weakness and numbness of her feet is diagnosed with an iatrogenic copper deficiency myelopathy induced by parenteral zinc overloading during chronic hemodialysis. Expand
Denture cream
TLDR
Denture cream contains zinc, and chronic excessive use may result in hypocupremia and serious neurologic disease, according to the authors, who identified four patients, one previously reported, with various neurologic abnormalities in the setting of hypocupremeia and hyperzincemia. Expand
Menkes's kinky hair syndrome. An inherited defect in copper absorption with widespread effects.
TLDR
Seven new cases of Menkes9s kinky hair syndrome are described from five families and low levels of serum copper and ceruloplasmin were found in all patients studied and a defect in the intestinal absorption of copper has been demonstrated, suggesting copper deficiency provides an adequate explanation of all the features of the disease. Expand
Clinicopathological analysis of hematological disorders in tube-fed patients with copper deficiency.
TLDR
Bicytopenia is likely to occur in tube-fed patients with copper deficiency, and copper deficiency appears to be associated with cytoplasmic vacuolization and electron-dense deposits in mitochondria in erythroid and myeloid cells. Expand
Subacute Combined Degeneration Due to Copper Deficiency
TLDR
A patient with sensory ataxia and spastic paraplegia from copper deficiency is reported whose MRI demonstrates abnormal signal restricted to the dorsal and lateral columns, providing clear radiological support of an association between hypocupremia and combined system degeneration. Expand
Copper deficiency and sideroblastic anemia associated with zinc ingestion
TLDR
Self‐administered zinc appears to have caused severe copper deficiency, with secondary anemia and neutropenia, and Physicians should be aware of this deleterious and completely reversible effect of megadose mineral therapy. Expand
...
1
2
...