When metals compete: a case of copper-deficiency myeloneuropathy and anemia

@article{Spain2009WhenMC,
  title={When metals compete: a case of copper-deficiency myeloneuropathy and anemia},
  author={R. Spain and T. Leist and E. Sousa},
  journal={Nature Clinical Practice Neurology},
  year={2009},
  volume={5},
  pages={106-111}
}
Background A 47-year-old woman with an otherwise unremarkable medical history was referred to the multiple sclerosis clinic by her primary neurologist for evaluation of a 2–3 year history of progressive knee and back pain, weakness, paresthesias, sensory loss, ataxia, and falls. During the same period, she had received blood transfusions for unexplained anemia and leukopenia. She had been wearing dentures for many years.Investigations Physical examination, neurological examinations (assessments… Expand
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Zinc poisoning from excessive denture fixative use masquerading as myelopolyneuropathy and hypocupraemia
TLDR
Questioning a patient about their denture fixative usage and checking if zinc is an ingredient may be considered during an investigation for myelopolyneuropathy when vitamin B12 deficiency is not a cause. Expand
[Peripheral neuropathy, myelopathy, cerebellar ataxia, and subclinical optic neuropathy associated with copper deficiency occurring 23 years after total gastrectomy].
We report a 61-year-old man with slowly progressive gait disturbance and paresthesia in the lower extremities following a total gastrectomy for gastric cancer 23 years previously. The patient… Expand
Cervical MRI of subacute myelo-optico-neuropathy
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MRI findings of old SMON patients are presented and it is suggested that these findings are useful to study the mechanism of clioquinol toxicity before using it to treat neurodegenerative diseases such as Alzheimer's disease. Expand
Copper deficiency myelopathy probably caused by long-lasting daily excessive intake of zink.
TLDR
A 39-year-old woman with slowly progressive spastic gait and paresthesia in the lower extremities and extreme unbalanced diet of having 15-20 oysters everyday over 5 years is reported, considered that zinc excess caused copper deficiency myelopathy. Expand
Approach to a case of myeloneuropathy
TLDR
The pattern of neurologic involvement and results obtained from a battery of biochemical tests often help in establishing the correct diagnosis of myeloneuropathy, a frequently encountered condition and often poses a diagnostic challenge. Expand
The role of the clinical biochemist in detection of zinc-induced copper deficiency
TLDR
A middle-aged woman with neutropenia and ataxia was found to have raised plasma zinc and profoundly low plasma copper concentrations and after the zinc prescription was stopped, her copper and zinc concentrations and neutropy normalized but she only had partial improvement in neurological status. Expand
The Miller Fisher Syndrome
TLDR
The eponym Miller Fisher syndrome (MFS) was named after Dr. Charles Miller Fisher after he described 3 patients with acute onset of ophthalmoplegia, ataxia and areflexia that followed acute upper respiratory infections in 1956. Expand
Zinc-containing denture adhesive: a potential source of excess zinc resulting in copper deficiency myelopathy
TLDR
A case of a 58-year-old man diagnosed with copper deficiency myelopathy possibly due to zinc-containing denture cream overuse is presented. Expand
Neural effects in copper deficient Menkes disease: ATP7A-a distinctive marker
TLDR
This review focused on the normal physiological function of the ATP7A gene with respect to their harmful outcome of the mutated gene and its associated deficiency which detriments the neural mechanism in Menkes patients. Expand
Neurologic presentations of nutritional deficiencies.
TLDR
This review discusses neurologic manifestations related to deficiency of key nutrients such as vitamin B(12), folate, copper, vitamin E, thiamine, and others and includes neurologic presentations caused by nutrient deficiencies in the setting of alcoholism. Expand
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