When ligand becomes receptor—tolerance via B7 signaling on DCs

@article{Finger2002WhenLB,
  title={When ligand becomes receptor—tolerance via B7 signaling on DCs},
  author={Erik B. Finger and Jeffrey A Bluestone},
  journal={Nature Immunology},
  year={2002},
  volume={3},
  pages={1056-1057}
}
1056 Despite the passage of more than ten years since the first demonstration that cytotoxic T lymphocyte–associated antigen 4–immunoglobulin (CTLA-4–Ig) therapy could induce long-term transplant survival and tolerance, the mechanistic basis of CTLA-4–Ig function remains poorly understood. The paradigm is that CTLA-4–Ig blocks the CD28-B7 (“B7” being either CD80 or CD86) costimulatory pathway that is essential for effective T cell expansion, differentiation and prevention of anergy. However, no… CONTINUE READING
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