When is thrombolysis justified in patients with acute ischemic stroke? A bioethical perspective.

@article{Furlan1997WhenIT,
  title={When is thrombolysis justified in patients with acute ischemic stroke? A bioethical perspective.},
  author={Anthony J. Furlan and George A. Kanoti},
  journal={Stroke},
  year={1997},
  volume={28 1},
  pages={214-8}
}
BACKGROUND Thrombolytic therapy for acute ischemic stroke raises several unsettled bioethical issues related to risk versus benefit. Excluding the National Institutes of Neurological Disorders and Stroke (NINDS) rt-PA trial, the risk of intracerebral hemorrhage averages 10.3%, and there is a 44% increase in the odds of death among fibrinolysis-treated patients. Some investigators have suggested that as yet unidentified subgroups may benefit despite an increased early risk of hemorrhage and… CONTINUE READING
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