When is the maximal effect of pre-administered systemic morphine on carrageenin evoked spinal c-Fos expression in the rat?

  title={When is the maximal effect of pre-administered systemic morphine on carrageenin evoked spinal c-Fos expression in the rat?},
  author={Prisca Honore and Victoria Chapman and Jaroslava Buritova and Jean Marie Besson},
  journal={Brain Research},

Intraplantar morphine depresses spinal c‐Fos expression induced by carrageenin inflammation but not by noxious heat

Results illustrate that peripheral effects of morphine preferentially occur during inflammatory states and outline the interest of extending clinical investigations of the possible use of local injection of morphine in various inflammatory pain states.

Concomitant Administration of Morphine and an N-Methyl-D-Aspartate Receptor Antagonist Profoundly Reduces Inflammatory Evoked Spinal c-Fos Expression

Conurrent micro-opioid receptor activation and N-methyl-D-aspartate receptor antagonism reduces nociceptive transmission at the level of the spinal cord, as shown by the reduction of carrageenin-evoked c-Fos expression.

Dose-related anti-inflammatory/analgesic effects of lornoxicam: A spinal c-Fos protein study in the rat

It is demonstrated that lORNoxicam reduces in parallel both the carrageenan-evoked oedema and spinal c-Fos expression, with clear evidence for a potent effect of low doses of lornoxicam.



Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord

The effect of systemic morphine on Fos-like immunoreactivity (FLI) evoked in the formalin test, a widely used model of persistent pain, and the dose-response relationship of morphine-induced suppression of FLI varied in different laminae indicate that analgesia from systemic opiates involves differential regulation of nociceptive processing in subpopulations of spinal nocICEptive neurons.

Differential effects of morphine on noxious stimulus-evoked fos-like immunoreactivity in subpopulations of spinoparabrachial neurons

Two distinct populations of spinoparabrachial neurons can be recognized on the basis of their expression of the c-fos gene in response to noxious stimulation, suggesting that injury can produce significant molecular changes in neurons even though the neuronal activity and pain associated with the injury is blocked by morphine.