When is cortisol a mineralocorticoid?

  title={When is cortisol a mineralocorticoid?},
  author={John N. Clore and Anton C. Schoolwerth and Charles O Watlington},
  journal={Kidney international},
  volume={42 6},
(1) Decreased 11 beta-OHSD activity permits binding of cortisol to the Type I (mineralocorticoid) receptor in humans, thereby producing spironolactone-inhibitable Na+ retention, hypokalemia and hypertension, the syndrome of apparent mineralocorticoid excess (AME). (2) Blockade of either the Type I receptor with spironolactone or the Type II (glucocorticoid) receptor with RU-486 does not consistently abolish the effects of stress level cortisol on Na+ retention and hypertension in acute studies… CONTINUE READING
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