When half is not enough: gene expression and dosage in the 22q11 deletion syndrome.

@article{Meechan2007WhenHI,
  title={When half is not enough: gene expression and dosage in the 22q11 deletion syndrome.},
  author={Daniel W. Meechan and Thomas M Maynard and Deepak Gopalakrishna and Yong-Sheng Wu and A-S Lamantia},
  journal={Gene expression},
  year={2007},
  volume={13 6},
  pages={
          299-310
        }
}
The 22q11 Deletion Syndrome (22q11DS, also known as DiGeorge or Velo-Cardio-Facial Syndrome) has a variable constellation of phenotypes including life-threatening cardiac malformations, craniofacial, limb, and digit anomalies, a high incidence of learning, language, and behavioral disorders, and increased vulnerability for psychiatric diseases, including schizophrenia. There is still little clear understanding of how heterozygous microdeletion of approximately 30-50 genes on chromosome 22 leads… CONTINUE READING
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