When fear is near: threat imminence elicits prefrontal-periaqueductal gray shifts in humans.

@article{Mobbs2007WhenFI,
  title={When fear is near: threat imminence elicits prefrontal-periaqueductal gray shifts in humans.},
  author={Dean Mobbs and Predrag Petrovic and Jennifer L. Marchant and Demis Hassabis and Nikolaus Weiskopf and Ben Seymour and Raymond J. Dolan and Christopher D. Frith},
  journal={Science},
  year={2007},
  volume={317 5841},
  pages={1079-83}
}
Humans, like other animals, alter their behavior depending on whether a threat is close or distant. We investigated spatial imminence of threat by developing an active avoidance paradigm in which volunteers were pursued through a maze by a virtual predator endowed with an ability to chase, capture, and inflict pain. Using functional magnetic resonance imaging, we found that as the virtual predator grew closer, brain activity shifted from the ventromedial prefrontal cortex to the periaqueductal… CONTINUE READING
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Magnetic Resonance Materials in Physics, Biology and Medicine

  • N. Weiskopf, C. Hutton, O. Josephs, R. Turner, R. Deichmann
  • 2007
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