When does Parkinson disease start?

Abstract

There is convincing evidence that the Parkinson disease neurodegenerative process begins many years before the onset of motor manifestations. Initial estimates based on nigral neuropathological findings or striatal dopamine imaging suggested a 5- to 6-year preclinical period. However, more recent evidence of Lewy body pathology in other neuronal populations… (More)
DOI: 10.1001/archneurol.2010.135

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Cite this paper

@article{Savica2010WhenDP, title={When does Parkinson disease start?}, author={Rodolfo Savica and Walter A. Rocca and J. Eric Ahlskog}, journal={Archives of neurology}, year={2010}, volume={67 7}, pages={798-801} }