When did Neanderthals and modern humans diverge?

@article{Beerli2003WhenDN,
  title={When did Neanderthals and modern humans diverge?},
  author={Peter Beerli and Scott V. Edwards},
  journal={Evolutionary Anthropology: Issues},
  year={2003},
  volume={11}
}
The availability of sequences from the mtDNA hypervariable region I and II of a specimen of the Neanderthal,1,2 Homo neanderthalensis, permits estimation of the time of divergence of Neanderthals and modern humans. Based on substitution rates derived from comparison of human and chimpanzee, Krings et al. provided an estimate of 550–690 KY1 and 317–741 KY2 before present for the split between the Neanderthal and contemporary human mtDNA. These estimates are dates for the split of the genes, and… 

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References

SHOWING 1-10 OF 16 REFERENCES

DNA sequence of the mitochondrial hypervariable region II from the neandertal type specimen.

TLDR
The results support the concept that the Neandertal mtDNA evolved separately from that of modern humans for a substantial amount of time and lends no support to the idea that they contributed mtDNA to contemporary modern humans.

Substitution rate variation among sites in mitochondrial hypervariable region I of humans and chimpanzees.

TLDR
The maximum-likelihood method was used to estimate the gamma shape parameter alpha for variable substitution rates among sites for HVI from humans and chimpanzees to provide estimates for future studies, and an alpha of 0.4 appears suitable for both humans and chimpanzee.

Evolution of the primate lineage leading to modern humans: phylogenetic and demographic inferences from DNA sequences.

  • N. TakahataY. Satta
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1997
TLDR
It is argued that the human ancestral lineage branched off from the NWM and OWM earlier than once thought and that significant demographic changes might have occurred at different evolutionary stages, particularly at the hominid stage.

PERSPECTIVE: GENE DIVERGENCE, POPULATION DIVERGENCE, AND THE VARIANCE IN COALESCENCE TIME IN PHYLOGEOGRAPHIC STUDIES

TLDR
It is shown that phylogeographic studies in vertebrates suggest that divergence of alleles in ancestral species can comprise from less than 10% to over 50% of the total divergence between sister species, suggesting that the problem of ancestral polymorphism in dating population divergence can be substantial.

Towards a theory of modern human origins: geography, demography, and diversity in recent human evolution.

TLDR
It is argued that the Neanderthal and modern lineages share a common ancestor in an African population between 350,000 and 250,000 years ago rather than in the earlier Middle Pleistocene; this ancestral population, which developed mode 3 technology (Levallois/Middle Stone Age), dispersed across Africa and western Eurasia in a warmer period prior to independent evolution towards Neanderthals and modern humans in stage 6.

On the estimation of ancestral population sizes of modern humans.

  • Z. Yang
  • Biology
    Genetical research
  • 1997
TLDR
The theory developed by Takahata and colleagues for estimating the effective population size of ancestral species using homologous sequences from closely related extant species was extended to take account of variation of evolutionary rates among loci, finding that among-locus rate variation does not have a significant effect on estimation of the current population size.

Compilation of human mtDNA control region sequences

TLDR
The organisation of a database for human mitochondrial control-region sequences is described, which comprises 4079 HVRI and 969 HVRII sequences and the available information about the individuals, from whom the sequences stem.

Substitution-rate variation among sites and the estimation of transition bias.

  • J. Wakeley
  • Biology
    Molecular biology and evolution
  • 1994
TLDR
A simple comparison of the proportions of transitions and transversions in recently diverged sequences underestimates the level of transition bias by approximately 15%.

Maximum likelihood estimation of population divergence times and population phylogenies under the infinite sites model.

  • R. Nielsen
  • Mathematics
    Theoretical population biology
  • 1998
In this paper, a maximum likelihood estimator of population divergence time based on the infinite sites model is developed. It is demonstrated how this estimator may be applied to obtain maximum