When can cyclodextrins be considered for solubilization purposes?

@article{Rao2003WhenCC,
  title={When can cyclodextrins be considered for solubilization purposes?},
  author={V. Uma Maheshwara Rao and Valentino J. Stella},
  journal={Journal of pharmaceutical sciences},
  year={2003},
  volume={92 5},
  pages={927-32}
}
This communication is intended to address the question: How can one determine, with minimum experimentation, if cyclodextrins (CDs) might be the right choice as solubilization enhancers for a given poorly water-soluble drug? The cyclodextrin utility number, U(CD), a dimensionless number, is introduced to assess the feasibility of the use of CDs in dosage forms. U(CD) is a lumped-parameter consisting of the dose of the drug, the workable amount of CD, the binding constant, and the drug… CONTINUE READING

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