When can AQP4 assist transporter-mediated K+ uptake?

  title={When can AQP4 assist transporter-mediated K+ uptake?},
  author={Leif Hertz and Dan Song and Junnan Xu and Ting Du and Li Gu and Liang Peng},
  booktitle={The Journal of general physiology},
We agree with Jin et al. (2013) that astrocytes accumulate extracellular K +. They discuss how differences in (a) resting extracellular space (ECS) volume, (b) diffusion limited water/K + transport, and (c) ECS contraction during K + reuptake may differently affect astrocytic K + uptake in wild-type animals and in mice with aqua-porin-4 (Aqp4) knockout. The… CONTINUE READING