When biochemistry meets structural biology: the cautionary tale of EmrE.

  title={When biochemistry meets structural biology: the cautionary tale of EmrE.},
  author={Shimon Schuldiner},
  journal={Trends in biochemical sciences},
  volume={32 6},
When biochemistry meets structural biology a more complete understanding of the mechanism of biological macromolecules is usually achieved. Several high-resolution structures of ion-coupled transporters have enriched the understanding of mechanisms of substrate recognition, translocation and coupling of substrate fluxes. However, two X-ray structures of EmrE, the smallest ion-coupled multi-drug transporter, raised questions over the veracity of the structural model and represented a cautionary… CONTINUE READING

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