When biochemistry meets structural biology: the cautionary tale of EmrE.

@article{Schuldiner2007WhenBM,
  title={When biochemistry meets structural biology: the cautionary tale of EmrE.},
  author={Shimon Schuldiner},
  journal={Trends in biochemical sciences},
  year={2007},
  volume={32 6},
  pages={252-8}
}
When biochemistry meets structural biology a more complete understanding of the mechanism of biological macromolecules is usually achieved. Several high-resolution structures of ion-coupled transporters have enriched the understanding of mechanisms of substrate recognition, translocation and coupling of substrate fluxes. However, two X-ray structures of EmrE, the smallest ion-coupled multi-drug transporter, raised questions over the veracity of the structural model and represented a cautionary… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 76 references

Comparison of three structures of the multidrug transporter EmrE

S. J. Fleishman, N. Ben-Tal
Curr . Opin . Struct . Biol . • 2006

Crystal structures of a multidrug transporter reveal a functionally rotating mechanism

S Murakami
Nature • 2006

Lessons from lactose permease.

Annual review of biophysics and biomolecular structure • 2006

Membrane-protein topology.

Nature reviews. Molecular cell biology • 2006

Similar Papers

Loading similar papers…