When are Psychotherapy and Pharmacotherapy Combinations the Treatment of Choice for Major Depressive Disorder?

@article{Thase2004WhenAP,
  title={When are Psychotherapy and Pharmacotherapy Combinations the Treatment of Choice for Major Depressive Disorder?},
  author={Michael E. Thase},
  journal={Psychiatric Quarterly},
  year={2004},
  volume={70},
  pages={333-346}
}
  • M. Thase
  • Published 2004
  • Psychology, Medicine
  • Psychiatric Quarterly
Treating major depressive disorder with the combination of psychotherapy and pharmacotherapy is highly valued by both psychiatrists and their patients. However, results of most systematic research studies suggest that this approach may be overvalued: evidence of additive benefits (in relation to the respective component therapies, alone) is meager. In this paper it is argued that the advantage of combined treatment may be limited to treatment of patients with more complex depressive disorders… Expand
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References

SHOWING 1-10 OF 49 REFERENCES
Treatment of major depression with psychotherapy or psychotherapy-pharmacotherapy combinations.
TLDR
New evidence is found in support of the widespread clinical impression that combined therapy is superior to psychotherapy alone for treatment of more severe, recurrent depressions. Expand
Cognitive therapy for major depressive disorder in primary care.
TLDR
At three-month follow-up cognitive therapy patients no longer differed from patients receiving treatment-as-usual, but this was mainly as a result of continuing improvement in the comparison group. Expand
Cognitive therapy and pharmacotherapy for depression. Singly and in combination.
TLDR
Combining cognitive therapy with pharmacotherapy did not markedly improve response over that observed for either modality alone, although such nonsignificant differences as were evident did favor the combined treatment. Expand
The role of Axis II comorbidity in the management of patients with treatment-resistant depression.
  • M. Thase
  • Psychology, Medicine
  • The Psychiatric clinics of North America
  • 1996
TLDR
In evaluating antidepressant-resistant patients, identification of pathologic personality traits or disorders may help provide important clues for future trials of both pharmacotherapy and psychotherapy, particularly in combination. Expand
Is psychotherapy an effective treatment for melancholia and other severe depressive states?
TLDR
There is not yet compelling evidence that melancholic patients respond to psychotherapy as well as they do to medications, but the potentially mediating effects of hypercortisolism, alterations of sleep neurophysiology, and disturbances of information processing and regional cerebral metabolism represent fertile grounds for future investigation. Expand
The efficacy of cognitive therapy in depression: a treatment trial using cognitive therapy and pharmacotherapy, each alone and in combination.
TLDR
An extensive study which compares cognitive therapy, antidepressant drugs and a combination of these two, in depressed patients seen either in general practice or an out-patient department and results are discussed in terms of Beck's cognitive theory of depression. Expand
Cognitive-behavioral management of drug-resistant major depressive disorder.
BACKGROUND The application of cognitive-behavioral treatment to drug-resistant major depression has received little research attention. METHOD Nineteen patients who failed to respond to at leastExpand
The prophylaxis of depressive episodes in recurrent depression following discontinuation of drug therapy: integrating psychological and biological factors.
TLDR
The key finding is that high specificity is of significant prophylactic benefit even for patients with a biological vulnerability for recurrence, and high treatment specificity is, in turn, reflected in longer times to recurrence. Expand
Predictors of drug response in depression.
TLDR
Clinical and biologic predictors of response, despite some interesting leads that may in the long term be of considerable importance, are not yet sufficiently established to be of routine clinical usefulness, although either dexamethasone nonsuppression or a shortened rapid eye movement latency may identify depressed patients who require biologic treatment. Expand
Treating major depression in primary care practice. Eight-month clinical outcomes.
TLDR
Severity of depressive symptoms was reduced more rapidly and more effectively among patients randomized to pharmacotherapy or psychotherapy than among patients assigned to a physician's usual care. Expand
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