When Toll-like receptor and T-cell receptor signals collide: a mechanism for enhanced CD8 T-cell effector function.

@article{Geng2010WhenTR,
  title={When Toll-like receptor and T-cell receptor signals collide: a mechanism for enhanced CD8 T-cell effector function.},
  author={Degui Geng and Liqin Zheng and Ratika Srivastava and Nicole Asprodites and Cruz Velasco-Gonzalez and Eduardo Davila},
  journal={Blood},
  year={2010},
  volume={116 18},
  pages={3494-504}
}
Emerging reports reveal that activating Toll-like receptor-2 (TLR2)-MyD88 signals in CD8 T lymphocytes enhances cytokine production and cytotoxicity; however, the signaling pathway remains undefined. In the present study, we examined the physiologic significance and molecular mechanisms involved in this process. We found that TLR2 engagement on T-cell… CONTINUE READING