When Things Go Wrong - Diseases and Disorders of the Human Brain

@inproceedings{Mantamadiotis2012WhenTG,
  title={When Things Go Wrong - Diseases and Disorders of the Human Brain},
  author={T. Mantamadiotis},
  year={2012}
}
Alzheimer’s Disease (AD) is the most frequent cause of dementia in the elderly. Prevalence is about 10% in populations of 65 years and older and it increases rapidly as life expectancy increases. Estimates indicate that there are around 36 million cases around the world, while associated costs are higher than US$ 600 billion (Wimo & Prince, 2010). The histopathological characteristics of AD are represented by two main lesions: senile plaques and neurofibrillary tangles (NFTs). The formers main… Expand
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References

SHOWING 1-10 OF 1,048 REFERENCES
In Search of Therapeutic Solutions for Alzheimer’s Disease
TLDR
Alzheimer’s Disease has triggered a plethora of hypotheses to explain its pathogenesis, possibly strengthened by the fact that no cure has yet been found for this devastating disease. Expand
Biological markers of Alzheimer's disease and mild cognitive impairment.
TLDR
An increasing number of studies suggest that supplementary use of these CSF markers preferably in combination, adds to the accuracy of an AD diagnosis, indicating the need of a highly sensitive and reliable approaches, selective for AD and based on biological markers. Expand
The molecular bases of Alzheimer's disease and other neurodegenerative disorders.
TLDR
This review is focused on the main protein aggregates responsible for neuronal death in both sporadic and familial forms of Alzheimer's disease, as well as on the alterations in the normal signaling pathways of functional neurons directly involved in neurodegeneration. Expand
Alzheimer's disease: A needle from the haystack
TLDR
Experiments in a mouse model for Alzheimer's disease have tracked down a possible cause for this early symptom: the extracellular accumulation of a soluble amyloid-β peptide assembly, dubbed Aβ*. Expand
Novel drugs affecting tau behavior in the treatment of Alzheimer's disease and tauopathies.
TLDR
It is noteworthy that tau oligomers with a prefilamentous structure appear to play a role at early stages of AD and tauopathies, but also in asymptomatic patients with Braak-stage I neuropathology, where clinical symptoms ofAD and NFTs in frontal cortex are absent. Expand
A clinical perspective: anti tau's treatment in Alzheimer's disease.
TLDR
It might be possible that in a near future the neurodegenerative process could be stopped, by the action of drugs that diminish its aggregation, or acting by altering its phosphorylation or filaments formation. Expand
Genetic and biochemical markers for Alzheimer's disease: recent developments
TLDR
Genetic and/or biochemical markers that support the clinical diagnosis and can distinguish AD from cognitive symptoms attributable to ageing and from other dementias will be of great value and are mandatory for the development of pharmacological treatment. Expand
Alzheimer's disease.
  • D. Selkoe
  • Medicine
  • Cold Spring Harbor perspectives in biology
  • 2011
TLDR
It is discussed how elucidating the genotype-to-phenotype relationships of familial forms of Alzheimer's disease has highlighted the importance of the misfolding and altered proteostasis of two otherwise soluble proteins, amyloid β-protein and tau, suggesting mechanism-based therapeutic targets that have led to clinical trials. Expand
Roles of Cholesterol and Lipids in the Etiopathogenesis of Alzheimer's Disease
TLDR
The investigation on the fine molecular mechanisms underlying the lipids influence in the etiopathogenesis of Alzheimer's disease may shed light into its treatment and medical management. Expand
Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease.
TLDR
A solid set of discoveries has strengthened the idea that altered patterns in the glia-neuron interactions constitute early molecular events within the cascade of cellular signals that lead to neurodegeneration in AD. Expand
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