When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157

@article{RojasRivera2017WhenPI,
  title={When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157},
  author={Diego Rojas-Rivera and Tinneke Delvaeye and Ria Roelandt and Wim Nerinckx and Koen Augustyns and Peter Vandenabeele and Mathieu M J Bertrand},
  journal={Cell Death and Differentiation},
  year={2017},
  volume={24},
  pages={1100-1110}
}
Accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes a state of cellular stress known as ER stress. The cells respond to ER stress by activating the unfolded protein response (UPR), a signaling network emerging from the ER-anchored receptors IRE1α, PERK and ATF6. The UPR aims at restoring ER protein-folding homeostasis, but turns into a toxic signal when the stress is too severe or prolonged. Recent studies have demonstrated links between the UPR and inflammation… CONTINUE READING