• Corpus ID: 11228634

When Nitrous Oxide is No Laughing Matter

  title={When Nitrous Oxide is No Laughing Matter},
  author={Victor C Baum},
First synthesized by Joseph Priestley in 1772, the psychotropic effects of nitrous oxide were first appreciated (in the first person) by Humphrey Davy. From the time that nitrous oxide was first used for analgesia by Horace Wells in December 1844 until 1956, nitrous oxide was considered to be completely benign. Although there were two isolated case reports, the first clear association of nitrous oxide and hematologic disease came in a report by Lassen, et al. in the Lancet in 1956.(1) They… 

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