When EGF is offside, magnesium is wasted.

  title={When EGF is offside, magnesium is wasted.},
  author={Shmuel Muallem and Orson W Moe},
  journal={The Journal of clinical investigation},
  volume={117 8},
Our understanding of magnesium (Mg(2+)) regulation has recently been catapulted forward by the discovery of several disease loci for monogenic disorders of Mg(2+) homeostasis. In this issue of the JCI, Groenestege et al. report that their study of a rare inherited Mg(2+) wasting disorder in consanguineous kindred shows that EGF acts as an autocrine/paracrine magnesiotropic hormone (see the related article beginning on page 2260). EGF stimulates Mg(2+) reabsorption in the renal distal convoluted… CONTINUE READING