When Degradation Elicits the Alarm: N-Terminal Degradation of NLRP1B Unleashes Its Inflammasome Activity.

@article{Eldeeb2019WhenDE,
  title={When Degradation Elicits the Alarm: N-Terminal Degradation of NLRP1B Unleashes Its Inflammasome Activity.},
  author={Mohamed A Eldeeb and Richard Peter Fahlman and Mansoore Esmaili and Edward A. Fon},
  journal={Molecular cell},
  year={2019},
  volume={74 4},
  pages={
          637-639
        }
}
Despite being among the first discovered mammalian innate immune sensor, NLRP1B (NLR pyrin domain-containing1B) activation and its molecular basis have remained elusive. Two recent studies have unveiled N-terminal degradation as a common mechanism for pathogen-mediated NLRP1B inflammasome activation in mammals. 
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