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Potential Role of BRCA 2 in a Mitotic Checkpoint after Phosphorylation by hBUBR 11
- Biology
- 2000
The results suggest that BRCA2 protein might be involved in a mitotic checkpoint in vivo after it has been phosphorylated by hBUBR1.
Tumor surveillance via the ARF-p53 pathway.
- Biology, MedicineGenes & development
- 1998
Emerging evidence is providing valuable insights into the molecular circuitry through which p19 modulates p53 activity as part of a checkpoint response to oncogenic, hyperproliferative signals.
Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1.
- BiologyCancer research
- 2000
The results suggest that BRCA2 protein might be involved in a mitotic checkpoint in vivo after it has been phosphorylated by hBUBR1.
Identification of a Functional Domain in a GADD45-mediated G2/M Checkpoint*
- Biology, ChemistryThe Journal of Biological Chemistry
- 2000
The binding of GADD45 to Cdc2 was insufficient to induce a G2/M arrest, and additional activity contributed by the DEDDDR residues may be necessary to regulate the G1/M checkpoint.
Shrinking Daughters: Rlm1-Dependent G1/S Checkpoint Maintains Saccharomyces cerevisiae Daughter Cell Size and Viability
- BiologyGenetics
- 2017
It is proposed that duplication of an “actin-organizing center” in late G1 may be required both to progress through START and to reestablish the actin cytoskeleton in daughter cells.
p55CDC/hCDC20 mutant induces mitotic catastrophe by inhibiting the MAD2-dependent spindle checkpoint activity in tumor cells.
- BiologyCancer letters
- 2003
Topoisomerase III Acts Upstream of Rad53p in the S-Phase DNA Damage Checkpoint
- BiologyMolecular and Cellular Biology
- 2001
It is shown that top3Δ mutants exhibit a RAD24-dependent delay in the G2 phase, suggesting a possible role for Top3p in the resolution of abnormal DNA structures or DNA damage arising during S phase, and a model proposing a role for these proteins in S phase is presented.
MPH1, a yeast gene encoding a DEAH protein, plays a role in protection of the genome from spontaneous and chemically induced damage.
- BiologyGenetics
- 2000
The characterized MPH1 gene from Saccharomyces cerevisiae, which carries the signature motifs of the DEAH family of helicases, suggests that MPH1 is not part of a hitherto known repair pathway.
Synergistic Effects of BubR1 and p53 Deficiency in Tumor Formation
- Biology
- 2006
The data indicates that the loss of BubR1 synergizes with p53 deficiency to increase the susceptibility of cancer formation in mice and alters the tumor spectrum of the p53 deficient mice.
The MRE11-RAD50 Complex
- Biology
- 2001
The MRE11-RAD50 protein complex, with homologs in bacteria, S. cerevisiae, and mammals, has emerged as a central player in the DNA transactions that preserve genomic integrity in yeast and mammalian cells.
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