Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease

@article{Dellen2007WheelRF,
  title={Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease},
  author={Anton van Dellen and Patricia M Cordery and Tara L. Spires and Colin Blakemore and Anthony J Hannan},
  journal={BMC Neuroscience},
  year={2007},
  volume={9},
  pages={34 - 34}
}
Huntington's disease (HD) is a neurodegenerative disorder predominantly affecting the cerebral cortex and striatum. Transgenic mice (R6/1 line), expressing a CAG repeat encoding an expanded polyglutamine tract in the N-terminus of the huntingtin protein, closely model HD. We have previously shown that environmental enrichment of these HD mice delays the onset of motor deficits. Furthermore, wheel running initiated in adulthood ameliorates the rear-paw clasping motor sign, but not an… CONTINUE READING
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