Wheel-running attenuates intravenous cocaine self-administration in rats: sex differences.

  title={Wheel-running attenuates intravenous cocaine self-administration in rats: sex differences.},
  author={Kelly P. Cosgrove and Robb G Hunter and Marilyn Carroll},
  journal={Pharmacology, biochemistry, and behavior},
  volume={73 3},
This experiment examines the effect of access to a running-wheel on intravenous cocaine self-administration in male and female rats. Rats maintained at 85% of their free-feeding body weight were first exposed to the running-wheel alone during the 6-h sessions until behavior stabilized for 14 days. Intravenous cannulae were then implanted, and the rats were trained to self-administer a low dose of cocaine (0.2 mg/kg) under a fixed-ratio (FR 1) schedule during the 6-h sessions, while the wheel… CONTINUE READING
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