Wheel running and environmental enrichment differentially modify exon‐specific BDNF expression in the hippocampus of wild‐type and pre‐motor symptomatic male and female Huntington's disease mice

@article{Zajac2010WheelRA,
  title={Wheel running and environmental enrichment differentially modify exon‐specific BDNF expression in the hippocampus of wild‐type and pre‐motor symptomatic male and female Huntington's disease mice},
  author={Michelle S. Zajac and Terence Y. C. Pang and N K Wong and B Weinrich and Leah Leang and Jeffery M Craig and Richard Saffery and Anthony John Hannan},
  journal={Hippocampus},
  year={2010},
  volume={20}
}
Brain‐derived neurotrophic factor (BDNF) is an essential neurotrophin and regulation of its expression is complex due to multiple 5′ untranslated exons which are separately spliced to a common coding exon to form unique mRNA transcripts. Disruption of BDNF gene expression is a key to the development of symptoms in Huntington's disease (HD), a fatal neurodegenerative condition. Abnormal epigenetic modifications are associated with reduced gene expression in late‐stage HD but such regulation of… 
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