What would be the observable consequences if phospholipid bilayer diffusion of drugs into cells is negligible?

@article{Kell2015WhatWB,
  title={What would be the observable consequences if phospholipid bilayer diffusion of drugs into cells is negligible?},
  author={Douglas B. Kell},
  journal={Trends in pharmacological sciences},
  year={2015},
  volume={36 1},
  pages={15-21}
}
For drug transport across (i.e., through) an intact biological membrane, two main routes are possible: drugs may cross (i) through the phospholipid bilayer portion of the membrane, and/or (ii) via proteinaceous pores or transporters. Perhaps surprisingly, there is in fact no direct scientific evidence that the first of these takes place at any significant rate because, in the experiments performed to date, it has neither been varied as an independent variable nor measured directly as a… CONTINUE READING
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