What would Treg-cell biology look like when viewed from a rationalized perspective?

  • Melvin Cohn
  • Published 2015 in European journal of immunology


The argument that Treg cells play a role in determining the Self (S)-Nonself (NS) discrimination (i.e. tolerance) is challenged based on two theoretical constructs, the two stage-two signal model for the S-NS discrimination and the Tritope model of TCR function. The conclusions are then tested by reinterpreting a published probing set of data purporting to… (More)
DOI: 10.1002/eji.201545799


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