What we truly know about occupation as a risk factor for ALS: A critical and systematic review

@article{Sutedja2009WhatWT,
  title={What we truly know about occupation as a risk factor for ALS: A critical and systematic review},
  author={Nadia A. Sutedja and Kathelijn Fischer and Jan Herman Veldink and Geert J.M.G. van der Heijden and Hans Kromhout and Dick J.J. Heederik and M. H.B. Huisman and John H. J. Wokke and Leonard H. van den Berg},
  journal={Amyotrophic Lateral Sclerosis},
  year={2009},
  volume={10},
  pages={295 - 301}
}
Occupational and environmental exposures may contribute to the risk of developing sporadic amyotrophic lateral sclerosis (ALS). To summarize the available evidence, a systematic review of the literature on occupation as a potential determinant of ALS was performed according to the MOOSE guidelines. From MEDLINE, EMBASE, CINAHL, and Cochrane databases, selected studies were methodologically appraised according to Armon's classification system for ALS risk factor studies. Each occupation studied… 
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TLDR
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TLDR
An association between consistently higher occupational Pb exposures and ALS is indicated, which support those of previously reported associations between ALS and specific occupations that commonly experience Pb exposure.
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The study results indicate that ALS risk may be increased by previous employment in occupations implying direct contact with the general public, in particular customers.
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TLDR
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TLDR
This study contributes to a growing body of literature implicating occupational- and hobby-related toxicant exposures in ALS etiology, and identifies increases in the risk of ALS associated with frequent participation in water sports, particularly waterskiing.
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Background—Recent data provide support for the concept that potentially modifiable exposures are responsible for sporadic amyotrophic lateral sclerosis (ALS). Objective—To evaluate environmental and…
Risk factors for amyotrophic lateral sclerosis : Lifestyle, environment and genetics
TLDR
It is shown that ALS has a complex etiology in which multiple genetic (and most probably also lifestyle and environmental) factors co-occur to cause ALS, and Co-occurring repeat expansions in C9orf72 and NIPA1 were identified.
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