What to do and what not to do in serological diagnosis of pertussis: recommendations from EU reference laboratories

@inproceedings{Guiso2010WhatTD,
  title={What to do and what not to do in serological diagnosis of pertussis: recommendations from EU reference laboratories},
  author={Nicole Guiso and Guy A. M. Berbers and Norman K Fry and Qiushui He and Marion Riffelmann and Carl-Heinz Wirsing von K{\"o}nig},
  booktitle={European Journal of Clinical Microbiology & Infectious Diseases},
  year={2010}
}
Bordetella pertussis-specific antibodies can be detected by enzyme-linked immunosorbent assays (ELISAs) or multiplex immunoassays. Assays use purified or mixed antigens, and only pertussis toxin (PT) is specific for B. pertussis. The interpretation of results can be based on dual-sample or single-sample serology using one or two cut-offs. The EU Pertstrain group recommends that: (i) ELISAs and multiplex immunoassays should use purified non-detoxified PT as an antigen, that they should have a… CONTINUE READING

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