What the shark immune system can and cannot provide for the expanding design landscape of immunotherapy.

@article{Criscitiello2014WhatTS,
  title={What the shark immune system can and cannot provide for the expanding design landscape of immunotherapy.},
  author={Michael F. Criscitiello},
  journal={Expert opinion on drug discovery},
  year={2014},
  volume={9 7},
  pages={725-39}
}
INTRODUCTION Sharks have successfully lived in marine ecosystems, often atop food chains as apex predators, for nearly one and a half billion years. Throughout this period they have benefitted from an immune system with the same fundamental components found in terrestrial vertebrates like man. Additionally, sharks have some rather extraordinary immune mechanisms which mammals lack. AREAS COVERED In this review the author briefly orients the reader to sharks, their adaptive immunity, and their… CONTINUE READING