What shapes eukaryotic transcriptional bursting?

@article{Nicolas2017WhatSE,
  title={What shapes eukaryotic transcriptional bursting?},
  author={Damien Nicolas and Nick E Phillips and Felix Naef},
  journal={Molecular bioSystems},
  year={2017},
  volume={13 7},
  pages={1280-1290}
}
Isogenic cells in a common environment present a large degree of heterogeneity in gene expression. Part of this variability is attributed to transcriptional bursting: the stochastic activation and inactivation of promoters that leads to the discontinuous production of mRNA. The diversity in bursting patterns displayed by different genes suggests the existence of a connection between bursting and gene regulation. Experimental strategies such as single-molecule RNA FISH, MS2-GFP or short-lived… CONTINUE READING

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