What proportion of symptomatic side effects in patients taking statins are genuinely caused by the drug? Systematic review of randomized placebo-controlled trials to aid individual patient choice

@article{Finegold2014WhatPO,
  title={What proportion of symptomatic side effects in patients taking statins are genuinely caused by the drug? Systematic review of randomized placebo-controlled trials to aid individual patient choice},
  author={Judith A. Finegold and Charlotte H. Manisty and Ben Goldacre and Anthony J G Barron and Darrel P. Francis},
  journal={European Journal of Preventive Cardiology},
  year={2014},
  volume={21},
  pages={464 - 474}
}
  • Judith A. Finegold, Charlotte H. Manisty, +2 authors Darrel P. Francis
  • Published 2014
  • Medicine
  • European Journal of Preventive Cardiology
  • Objective Discussions about statin efficacy in cardiovascular prevention are always based on data from blinded randomized controlled trials (RCTs) comparing statin to placebo; however, discussion of side effects is not. Clinicians often assume symptoms occurring with statins are caused by statins, encouraging discontinuation. We test this assumption and calculate an evidence-based estimate of the probability of a symptom being genuinely attributable to the statin itself. Methods We identified… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 142 CITATIONS, ESTIMATED 52% COVERAGE

    Statins for primary prevention in people with a 10% 10-year cardiovascular risk: too much medicine too soon?

    Lack of adverse effect of statin therapy on common muscle-related adverse events

    • Rory Collins
    • Medicine
    • European journal of preventive cardiology
    • 2015
    VIEW 2 EXCERPTS
    CITES METHODS

    FILTER CITATIONS BY YEAR

    2014
    2020

    CITATION STATISTICS

    • 2 Highly Influenced Citations

    • Averaged 11 Citations per year from 2018 through 2020

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 46 REFERENCES