What nephrologists need to know about gadolinium

@article{Penfield2007WhatNN,
  title={What nephrologists need to know about gadolinium},
  author={Jeffrey G. Penfield and Robert F. Reilly},
  journal={Nature Clinical Practice Nephrology},
  year={2007},
  volume={3},
  pages={654-668}
}
Gadolinium chelates are commonly used to improve tissue contrast in MRI. Until recently the use of gadolinium was thought to be risk-free compared with alternative contrast agents. Recent studies, however, have raised serious concerns regarding the safety of gadolinium chelates. Although safe in patients with normal kidney function, administration of these agents in people with renal dysfunction can result in up to three clinical problems that the nephrologist should be familiar with. The first… 

Application of extracellular gadolinium-based MRI contrast agents and the risk of nephrogenic systemic fibrosis.

Despite the NSF risk, contrast-enhanced MRI is a safe diagnostic procedure which can be used reliably and safely even in patients with severe renal failure, and does not necessarily have to be replaced by other methods.

Gadolinium-Induced Fibrosis.

It is proposed that the name gadolinium-induced fibrosis (GIF) more accurately reflects the totality of knowledge regarding this disease and use of high-risk GBCAs, such as formulated gadodiamide, should be avoided in patients with renal disease.

Nephrogenic systemic fibrosis and the use of gadolinium-based contrast agents

Nephrogenic systemic fibrosis (NSF) is a disease seen exclusively in patients with decreased renal function. The use of gadolinium-based contrast agents (GBCAs) has a strong association with NSF.

Gadodiamide-associated nephrogenic systemic fibrosis: why radiologists should be concerned.

Development of NSF was strongly associated with gadodiamide administration in the setting of either acute hepatorenal syndrome or dialysis-dependent chronic renal insufficiency.

Gadolinium-associated plaques: a new, distinctive clinical entity.

Doctors should be aware that GAP can occur without NSF or renal disease and is associated with the use of radiologic dyes, which is related to a particular type of gadolinium used for contrast-enhanced radiologic studies.

Is it Safe to Use Gadolinium-Based Contrast Agents in Mri?

  • R. PullicinoK. Das
  • Medicine, Biology
    The journal of the Royal College of Physicians of Edinburgh
  • 2017
The development of the gadolinium contrast agents, their use and the advice related to this new information are reviewed.

Risk of nephrogenic systemic fibrosis: evaluation of gadolinium chelate contrast agents at four American universities.

The benchmark incidence of nephrogenic systemic fibrosis related to the confirmed use of different gadolinium chelate contrast agents at four U.S. university tertiary care centers was much greater at the two centers where gadodiamide was used than at theTwo center where gadopentetate dimeglumine was used.

Pathogenesis, Diagnosis, and Therapy

To reduce the risk of NSF, renal function must be determined before exposure to gadolinium-containing MR contrast agents, and a sufficient period of time for elimination of the contrast agent from the body should be allowed before readministration of the Contrast Agent.

Gadolinium and nephrogenic systemic fibrosis.

  • V. Runge
  • Medicine
    AJR. American journal of roentgenology
  • 2009
The scientific literature, and specifically all prospective, controlled clinical trials, confirm that the five gadolinium chelates currently on the U.S. market with extracellular distribution—in order of their FDA approval, Magnevist, ProHance, Omniscan, OptiMARK, and MultiHance are safe.
...

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