What mouse mutants teach us about extracellular matrix function.

@article{Aszodi2006WhatMM,
  title={What mouse mutants teach us about extracellular matrix function.},
  author={Attila Aszodi and Kyle R. Legate and Inaam A. Nakchbandi and Reinhard F{\"a}ssler},
  journal={Annual review of cell and developmental biology},
  year={2006},
  volume={22},
  pages={591-621}
}
For many years the extracellular matrix was viewed as a benign scaffold for arranging cells within connective tissues, but it is now being redefined as a dynamic, mobile, and flexible key player in defining cellular behavior. Gene targeting, transgene expression, and spontaneous mutations of extracellular matrix proteins in mice have greatly accelerated our mechanistic view of the structural and instructive functions of the extracellular matrix in developmental and regenerative processes. This… CONTINUE READING

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