What makes us tick? Functional and neural mechanisms of interval timing

  title={What makes us tick? Functional and neural mechanisms of interval timing},
  author={Catalin V. Buhusi and Warren H. Meck},
  journal={Nature Reviews Neuroscience},
Time is a fundamental dimension of life. It is crucial for decisions about quantity, speed of movement and rate of return, as well as for motor control in walking, speech, playing or appreciating music, and participating in sports. Traditionally, the way in which time is perceived, represented and estimated has been explained using a pacemaker–accumulator model that is not only straightforward, but also surprisingly powerful in explaining behavioural and biological data. However, recent… 
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Introduction to the neurobiology of interval timing.
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Exploring the 4th Dimension: Hippocampus, Time, and Memory Revisited
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Neuropsychological mechanisms of interval timing behavior.
  • M. Matell, W. Meck
  • Biology, Psychology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2000
Timing models proposing the use of coincidence-detection mechanisms (e.g., the detection of simultaneous activity across multiple neural inputs) appear to be the most compatible with known neural mechanisms.
The neural representation of time
Neuropharmacology of timing and time perception.
  • W. Meck
  • Psychology, Biology
    Brain research. Cognitive brain research
  • 1996
Functional and neural mechanisms of interval timing
Foreword, Robert Rousseau Introduction: The Persistence of Time, Warren H. Meck FUNCTIONAL MECHANISMS A Concise Introduction to Scalar Timing Theory, Russell M. Church General Learning Models: Timing
Scalar expectancy theory and peak-interval timing in humans.
It is demonstrated that humans show the same qualitative timing properties that other animals do, but with some quantitative differences.
The neural basis of temporal processing.
It is suggested that, given the intricate link between temporal and spatial information in most sensory and motor tasks, timing and spatial processing are intrinsic properties of neural function, and specialized timing mechanisms such as delay lines, oscillators, or a spectrum of different time constants are not required.
Neuropsychology of timing and time perception
  • W. Meck
  • Psychology, Biology
    Brain and Cognition
  • 2005
Not “just” a coincidence: Frontal‐striatal interactions in working memory and interval timing
The principles derived from these biologically based models also fit well with a family of behaviourally based models that emphasise the importance of time in many working memory phenomena.
Toward a neurobiology of temporal cognition: advances and challenges