What makes placebo-controlled trials unethical?

  title={What makes placebo-controlled trials unethical?},
  author={Franklin G. Miller and H. Brody},
  journal={The American journal of bioethics : AJOB},
  volume={2 2},
The leading ethical position on placebo-controlled clinical trials is that whenever proven effective treatment exists for a given condition, it is unethical to test a new treatment for that condition against placebo. Invoking the principle of clinical equipoise, opponents of placebo-controlled trials in the face of proven effective treatment argue that they (1) violate the therapeutic obligation of physicians to offer optimal medical care and (2) lack both scientific and clinical merit. We… CONTINUE READING