What limits the velocity of fast-skeletal muscle contraction in mammals?

@article{Nyitrai2006WhatLT,
  title={What limits the velocity of fast-skeletal muscle contraction in mammals?},
  author={Mikl{\'o}s Nyitrai and Rosetta Rossi and Nancy Adamek and Maria Antonietta Pellegrino and Roberto Bottinelli and Michael A. Geeves},
  journal={Journal of molecular biology},
  year={2006},
  volume={355 3},
  pages={
          432-42
        }
}
In rat skeletal muscle the unloaded shortening velocity (Vo) is defined by the myosin isoform expressed in the muscle fibre. In 2001 we suggested that ADP release from actomyosin in solution (controlled by k(-AD)) was of the right size to limit Vo. However, to compare mechanical and solution kinetic data required a series of corrections to compensate for the differences in experimental conditions (0.5 M KCl, 22 degrees C for kinetic assays of myosin, 200 mM ionic strength, 12 degrees C to… CONTINUE READING
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